Wikipedia:WikiProject Cell Signaling

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Some Wikipedians have formed a project to better organize information in articles related to Cell Signaling. This page and its subpages contain their suggestions; it is hoped that this project will help to focus the efforts of other Wikipedians. If you would like to help, please inquire on the talk page and see the to-do list there.

For more information on WikiProjects, please see Wikipedia:WikiProject and Wikipedia:WikiProject/Best practices.

Contents 1 Title 2 Scope 2.1 Goals 2.2 Target audience 3 Parentage 4 Similar WikiProjects 5 Participants 6 Structure 7 Hierarchy definition 8 Projects 9 Tasks 10 Adopt an article 11 General strategy and discussion forums 12 Templates 12.1 Infoboxes 12.2 Other templates 13 Categories 14 Lists 15 Articles 16 Archives 17 Sister Project links

[edit] Title

WikiProject on Cell Signaling

[edit] Scope

This project is dedicated to improving and organising the Wikipedia articles on cell signaling to provide a convinient and reliable reference of the known signal transduction pathways. It covers the pathway pages and individual protein pages related to them.

[edit] Goals

• Creating comprehensive articles for each known cell signaling pathway
• Organising cell signaling articles with navigation boxes like these: Wikipedia:WikiProject Molecular and Cellular Biology#Protein topics navigation boxes.
• Organising and creating articles on notable proteins involved in signaling pathways.
• Providing each pathway with a clear diagram of its structure.
• Clearly citing sources, especially for active research topics

[edit] Target audience

• Introduction to pathway articles should be make minimal use of jargon and be kept relatively simple
• Subsections and protein pages can be more technical

[edit] Parentage

This is a daughter project of WikiProject Molecular and Cellular Biology

[edit] Similar WikiProjects

WikiProject Clinical medicine and WikiProject Drugs may be relevant to this project.

[edit] Participants

Name	Talk page	Special interests
Peter Znamenskiy	Talk	Cell culture and adult stem cells
Rockpocket	Talk	G-protein coupled receptors
David Iberri	Talk	Embryogenesis (especially nervous system development)
John Schmidt	Talk	illustrations
Gacggt	Talk	Skeletal Muscle biology, Akt pathway, NF-kappaB pathway, some GPCRs, Neurotrophins, MuSK, agrin, Neuromuscular junction, etc
Kohlasz	Talk	Chemotaxis
EquationDoc	Talk	Pathways involved in cancer prevention and formation
JE.at.UWO	Talk	Immunology, development, endocrinology and reproductive physiology.

[edit] Structure

Proposed structure of a pathway article:

• General introduction - keep it simple and clear
• History/Discovery - discovery, seminal papers
• Mechanism - the proteins involved and how they interact.
• Role - the role of the pathway
• Human disease - alternatively this can be incorporated into the previous section
• Current research - recent advances, future directions

For individual proteins, see suggestions in Wikipedia:WikiProject_Molecular_and_Cellular_Biology#Structures

Proposed scheme for pathway diagrams is described here. Please do comment and contribute.

[edit] Hierarchy definition

No classification of this project has been defined.

[edit] Projects

[edit] Tasks

• Complete - build a sample pathway article: Hedgehog signaling pathway
• Complete - resolve the Cell signaling/Signal transduction merger, no merge
• Compile list of existing cell signaling articles - please add articles to the list below
• Design a convention for drawing pathway diagrams

[edit] Adopt an article

Similar to the Collaboration of the week, but on a smaller scale, you might want to "adopt" an article. This would involve doing the research, writing, and picture-taking (if possible) for either a non-existent article or a stub. Of course, everyone else can still edit an adopted article, and you can work on other things too, but the idea is to find a focus for a while, to try and build up the number of quality articles the Project has produced.

• Example article: User:Example

[edit] General strategy and discussion forums

• /General
• /Strategy

[edit] Templates

[edit] Infoboxes

[edit] Other templates

{{Template:Cell Signaling Project}}

This article is part of WikiProject Cell Signaling, an attempt to better organise information in articles related to cell signaling and signal transduction. If you would like to participate, you can edit the article attached to this page, or visit the Cell Signaling WikiProject project, where you can join the project and/or contribute to the discussion.

{{Template:Cell_signaling}}

{{Template:Lipid_signaling}}

{{Template:TGF beta signaling}}

[edit] Categories

• Category:Signal transduction

[edit] Lists

[edit] Articles

• Signal transduction/Cell signaling

Ligand (biochemistry)

Receptor (biochemistry)

Second messenger

Protein kinase

Transcription factor

• Akt signaling pathway

PI3K

PTEN

Akt

PDK1

PDK2

SHIP2

PHLPP

Tsc

mTOR

p70S6K

4E-BP

GSK-3

Catenin

NFAT

FOXO

BAD

• Apoptosis

Bcl-2

Caspase

• Cell cycle
• Cell division
• Cellular differentiation
• Cell proliferation
• Chemotaxis

• Calcium signaling

Calmodulin

• Cytokine
• Hedgehog signaling pathway

Sonic Hedgehog

Smoothened

• Integrin
• Lipid signaling

Diacylglycerol

Inositol triphosphate

Inositol triphosphate receptor

Phospholipase

• JAK-STAT pathway

STAT protein

JAK

• Mammalian target of rapamycin
• MAPK/ERK pathway

Epidermal growth factor receptor

Ras

Raf

MAPK

Mitogen-activated protein kinase

• NF-kB
• Notch signaling
• p53
• TGF beta signaling pathway

Activin

Transforming growth factor

SMAD (protein)

R-SMAD

I-SMAD

• Wnt signaling pathway

Catenin

GSK-3

[edit] Archives

• #1

[edit] Sister Project links

Wikimedia Commons has media related to: Cell Signaling Wikimedia Commons has media related to: Cell Signaling Wikiquote has a collection of quotations related to: WikiProject Cell Signaling Look up WikiProject Cell Signaling in Wiktionary, the free dictionary. Wikinews has news related to: Cell Signaling Wikinews has news related to: Cell Signaling

Wikibooks has more on the topic of WikiProject Cell Signaling Wikisource has original text related to this article: WikiProject Cell Signaling Wikispecies has information related to: Cell Signaling Meta has a page about this at: Cell Signaling

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