Yohimbine

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Yohimbine
Systematic (IUPAC) name
17α-hydroxy-yohimban-16α- carboxylic acid methyl ester
Identifiers
CAS number	146-48-5
ATC code	G04BE04
PubChem	8969
Chemical data
Formula	C₂₁H₂₆N₂O₃
Mol. mass	354.44 g/mol (base) 390.90 g/mol (hydrochloride)
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Yohimbine, also known under the outdated names quebrachin, aphrodin, corynine, yohimvetol and hydroergotocin, is the principal alkaloid of the bark of the West-African tree Pausinystalia yohimbe Pierre (formerly Corynanthe yohimbe), family Rubiaceae (Madder family). There are 31 other yohimbane alkaloids found in Yohimbe.

[edit] Pharmacology

Yohimbine is a selective competitive alpha2-adrenergic receptor antagonist that is sometimes used as an alternative, though unproven, treatment for erectile dysfunction. ^[1]

Higher doses of oral yohimbine create numerous side effects such as rapid heart rate, high blood pressure, and overstimulation. Yohimbine may produce anxiety. This herbal agent causes insomnia and sleeplessness in many users.

Some internet shops sell expensive formulations of yohimbine for transdermal delivery to effect a local reduction of adipose tissue, although there is no evidence that it is effective. Demand for products of this kind is frequently found in the bodybuilding community.

Controlled studies suggest that it is not a particularly effective treatment for impotence, and evidence of increased sex drive (libido) is anecdotal only [1]. It has significant side effects such as postural hypotension and can cause anxiety reactions.

In veterinary medicine, yohimbine is used to reverse anesthesia from the drug xylazine in small and large animals.

[edit] References

^ http://www.nlm.nih.gov/medlineplus/druginfo/uspdi/202639.html] National Institute of Health

[edit] External links

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