Angiotensin-converting enzyme

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Angiotensin I converting enzyme PDB [1]
Angiotensin I converting enzyme
Identifiers
Symbol	ACE CD143, CD143
HUGO	2707
Entrez	1636
OMIM	106180
RefSeq	NM_000789
UniProt	P12821
Other data
EC number	3.4.15.1
Locus	Chr. 17 q23

Angiotensin I converting enzyme (ACE, EC 3.4.15.1) is an exopeptidase.

Contents 1 Functions 2 Synonyms 3 Genetics 4 See also 5 References 6 External links

[edit] Functions

It has two primary functions:

• it catalyses the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. ^[1]

• it is involved in the inactivation of bradykinin, a potent vasodilator.

These two actions of ACE make it an ideal target in the treatment of conditions such as high blood pressure, heart failure, diabetic nephropathy and type 2 diabetes mellitus. Inhibition of ACE (by ACE inhibitors) results in decreased formation of Angiotensin II (a far more potent vasoconstrictor than Angiotensin I) and decreased inactivation of bradykinin.

[edit] Synonyms

ACE is also known as:

• peptidyl dipeptidase A
• carboxycathepsin
• kininase II (kinin-kallikrein system)
• CD 143
• ACE1

[edit] Genetics

The ACE gene, ACE, encodes 2 isozymes. The somatic isozyme is expressed in many tissues, including vascular endothelial cells, epithelial kidney cells, and testicular Leydig cells, whereas the germinal is expressed only in sperm.

[edit] See also

• Renin-angiotensin system
• ACE inhibitors

[edit] References

1. ^ Physiology at MCG 7/7ch09/7ch09p16

[edit] External links

• MeSH Angiotensin+Converting+Enzyme