CD22

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CD22 molecule
Identifiers
Symbol	CD22
HUGO	1643
Entrez	933
OMIM	107266
RefSeq	NM_001771
UniProt	P20273
Other data
Locus	Chr. 19 q13.1

CD22 or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins.^[1] It is a sugar binding transmembrane protein, which specifically binds sialic acid with an immunoglobulin (Ig) domain located at its N-terminus. The presence of Ig domains makes CD22 a member of the immunoglobulin superfamily. CD22 functions as an inhibitory receptor for B cell receptor (BCR) signalling. EBV (Ebstein Bar Virus) is known to bind to the B lymphocyte via the CD22 receptor.

[edit] External links

• MeSH CD22+Antigen

[edit] References

1. ^ Crocker P, Clark E, Filbin M, Gordon S, Jones Y, Kehrl J, Kelm S, Le Douarin N, Powell L, Roder J, Schnaar R, Sgroi D, Stamenkovic K, Schauer R, Schachner M, van den Berg T, van der Merwe P, Watt S, Varki A (1998). "Siglecs: a family of sialic-acid binding lectins". Glycobiology 8 (2): v. PMID 9498912.