DC-SIGN

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CD209 molecule
Identifiers
Symbol	CD209
HUGO	1641
Entrez	30835
OMIM	604672
RefSeq	NM_021155
UniProt	Q9NNX6
Other data
Locus	Chr. 19 p13

DC-SIGN or CD209 is a C-type lectin receptor present on both macrophages and Dendritic cells.

DC-SIGN on macrophages recognises and binds to mannose type carbohydrates, a class of Pathogen associated molecular patterns PAMPs commonly found on viruses, bacteria and fungi. This binding interaction activates phagocytosis.^Ref1

On myeloid and pre-plasmacytoid dendritic cells DC-SIGN mediates dendritic cell rolling interactions with blood endothelium and activation of CD4+ T cells, as well as recognition of pathogen haptens.

Role in HIV infection

This molecule is involved in the initial stages of the Human Immunodeficiency Virus infection, as the HIV gp120 molecule causes co-internalization of the DC-SIGN molecule and HIV virion.

The dendritic cell then migrates to the cognate lymphoid organ, whereupon recycling of the DC-SIGN/HIV virion complex to the cell periphery facilitates HIV infection of T cells by interaction between DC-SIGN and ICAM-3.

''''References'''' ^{ref 1}Mc Greal et al (2005) Ligand recognition by antigen presenting cell C-type lectin receptors. 'Current Opinion in Immunology'. 17:18-24