Bretylium
From Wikipedia, the free encyclopedia
 |
|
|
Bretylium
|
|
| Systematic (IUPAC) name | |
| (2-bromophenyl)methyl-ethyl-dimethyl-ammonium | |
| Identifiers | |
| CAS number | |
| ATC code | C01 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C11H17BrN+ |
| Mol. mass | 243.163 g/mol |
| Pharmacokinetic data | |
| Bioavailability | NA |
| Protein binding | NA |
| Metabolism | None |
| Half life | 7-8 hours |
| Excretion | Renal |
| Therapeutic considerations | |
| Pregnancy cat. | |
| Legal status | |
| Routes | IV, IM |
Bretylium (also bretylium tosylate) blocks the release of noradrenaline from the peripheral sympathetic nervous system, and is used in emergency medicine, cardiology, & other specialties for the acute management of ventricular tachycardia & ventricular fibrilation. It is contraindicated in patients with AV (atrioventricular) heart block or digoxin toxicity. It probably should not be used at other times.
 |
This pharmacology-related article is a stub. You can help Wikipedia by expanding it. |
|
|
|
|---|---|
| class Ia | Ajmaline, Disopyramide, Prajmaline, Procainamide, Quinidine, Sparteine |
| class Ib | Aprindine, Lidocaine, Mexiletine, Tocainide |
| class Ic | Encainide, Flecainide, Lorcainide, Moricizine, Propafenone |
| class II | Propranolol, Metoprolol, Nadolol, Atenolol, Acebutolol, Pindolol see Beta blockers (C07) |
| class III | Amiodarone, Bretylium tosylate, Bunaftine, Dofetilide, Ibutilide, Sotalol |
| class IV | Verapamil, Diltiazem see Calcium channel blockers (C08) |
| class V | Adenosine, Atropine, Digoxin |
