Disopyramide

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Disopyramide
Systematic (IUPAC) name
4-dipropan-2-ylamino-2-phenyl-2-pyridin-2-yl-butanamide
Identifiers
CAS number	3737-09-5
ATC code	C01BA03
PubChem	3114
DrugBank	APRD00507
Chemical data
Formula	C21H29N3O
Mol. mass	339.475 g/mol
Pharmacokinetic data
Bioavailability	High
Protein binding	50% to 65% (concentration-dependent)
Metabolism	Hepatic (CYP3A4-mediated)
Half life	6.7 hours (range 4 to 10 hours)
Excretion	Renal (80%)
Therapeutic considerations
Pregnancy cat.	B2(AU) C(US)
Legal status	POM(UK) ℞-only(US)
Routes	Oral, intravenous

Disopyramide (INN, trade names Norpace® and Rythmodan®) is an antiarrhythmic medication. It is a Class Ia antiarrythmic used in the treatment of ventricular tachycardias. It has no effect on alpha or beta adrenergic receptors.

[edit] External links

• Disopyramide on RxList

v • d • e Antiarrhythmic agents (C01B)
class Ia	Ajmaline, Disopyramide, Prajmaline, Procainamide, Quinidine, Sparteine
class Ib	Aprindine, Lidocaine, Mexiletine, Tocainide
class Ic	Encainide, Flecainide, Lorcainide, Moricizine, Propafenone
class II	Propranolol, Metoprolol, Nadolol, Atenolol, Acebutolol, Pindolol see Beta blockers (C07)
class III	Amiodarone, Bretylium tosylate, Bunaftine, Dofetilide, Ibutilide, Sotalol
class IV	Verapamil, Diltiazem see Calcium channel blockers (C08)
class V	Adenosine, Atropine, Digoxin