Calcitriol receptor
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vitamin D (1,25- dihydroxyvitamin D3) receptor
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| Identifiers | |
| Symbol | VDR |
| HUGO | 12679 |
| Entrez | 7421 |
| OMIM | 601769 |
| RefSeq | NM_000376 |
| UniProt | P11473 |
| Other data | |
| Locus | Chr. 12 q12-q14 |
The calcitriol receptor, also known as the Vitamin D receptor (VDR) is a member of the steroid hormone family of nuclear receptors. Upon activation by vitamin D, the VDR forms a heterodimer with the retinoid-X receptor and binds to hormone response elements on DNA resulting in expression or transrepression of specific geneproducts.
Glucocorticoids are known to decrease expression of VDR which is expressed in most tissues of the body. Its most well known function is the regulation of intestinal transport of calcium.
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CAP - CBF - E2F - KlF - Nanog - NF-kB - Oct-4 - P300/CBP - PIT-1 - Rho/Sigma - R-SMAD - Sox2 - Sp1 - STAT (STAT1, STAT3, STAT5)
Basic-helix-loop-helix: AhR - HIF - MYC - Twist - Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6)
Basic leucine zipper: C/EBP - CREB - AP-1
Basic helix-loop-helix leucine zipper: MITF - SREBP
Nuclear receptors: subfamily 1 (Thyroid hormone, RAR, PPAR, LXR, FXR, Calcitriol, PXR, CAR) - subfamily 2 (HNF4, RXR) - subfamily 3/Steroid hormone (Estrogen, Estrogen related, Glucocorticoid, Mineralocorticoid, Progesterone, Androgen) - subfamily 0 (NR0B1)
