STAT1
From Wikipedia, the free encyclopedia
 |
|
| STAT1 bound to DNA | |
|
signal transducer and activator of transcription 1, 91kDa
|
|
| Identifiers | |
| Symbol | STAT1 |
| HUGO | 11362 |
| Entrez | 6772 |
| OMIM | 600555 |
| RefSeq | NM_007315 |
| UniProt | P42224 |
| Other data | |
| Locus | Chr. 2 q32.2-32.3 |
STAT1 homodimers are involved in type II interferon signalling, and binds to the GAS (Interferon-Gamma Activated Sequence) promoter to induce expression of ISG (Interferon Stimulated Genes).
[edit] References
CAP - CBF - E2F - KlF - Nanog - NF-kB - Oct-4 - P300/CBP - PIT-1 - Rho/Sigma - R-SMAD - Sox2 - Sp1 - STAT (STAT1, STAT3, STAT5)
Basic-helix-loop-helix: AhR - HIF - MYC - Twist - Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6)
Basic leucine zipper: C/EBP - CREB - AP-1
Basic helix-loop-helix leucine zipper: MITF - SREBP
Nuclear receptors: subfamily 1 (Thyroid hormone, RAR, PPAR, LXR, FXR, Calcitriol, PXR, CAR) - subfamily 2 (HNF4, RXR) - subfamily 3/Steroid hormone (Estrogen, Estrogen related, Glucocorticoid, Mineralocorticoid, Progesterone, Androgen) - subfamily 0 (NR0B1)
