Cation channels of sperm

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cation channel, sperm associated 1
Identifiers
Symbol	CATSPER1
HUGO	17116
Entrez	117144
OMIM	606389
RefSeq	NM_053054
UniProt	Q8NEC5
Other data
Locus	Chr. 11 q12.1

cation channel, sperm associated 2
Identifiers
Symbol	CATSPER2
HUGO	18810
Entrez	117155
OMIM	607249
RefSeq	NM_172097
UniProt	Q96P55
Other data
Locus	Chr. 15 q13-q15

cation channel, sperm associated 3
Identifiers
Symbol	CATSPER3
HUGO	20819
Entrez	347732
OMIM	609120
RefSeq	NM_178019
UniProt	Q86XQ3
Other data
Locus	Chr. 5 q31.2

cation channel, sperm associated 4
Identifiers
Symbol	CATSPER4
HUGO	23220
Entrez	378807
OMIM	609121
RefSeq	XM_371237
UniProt	Q7RTX7
Other data
Locus	Chr. 1 p35.3

Cation channels of sperm: This small family of ion channels, normally referred to as Catsper channels or CatSper, is related to the two-pore channels and distantly related to TRP channels. The 4 members of this family form voltage-gated Ca²⁺ channels that seem to be specific to sperm. These channels are required form proper fertilization. The study of these channels has been slow because they do not traffick to the cell membrane in many heterologous systems.