TRPV6
From Wikipedia, the free encyclopedia
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transient receptor potential cation channel, subfamily V, member 6
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| Identifiers | |
| Symbol | TRPV6 ECAC2 |
| HUGO | 14006 |
| Entrez | 55503 |
| OMIM | 606680 |
| RefSeq | NM_018646 |
| UniProt | Q9H1D0 |
| Other data | |
| Locus | Chr. 7 q34-7q35 |
TRPV6 is a membrane calcium channel which is responsible for the first step in calcium absorption in the intestine. It was first named CAT1 [1], or ECaC2, and has been described in the intestine in several species, including humans [2]. It is located in the apical brush-border membrane of the intestinal enterocyte where is regulates calcium entry into the cell. It is most abundant in the proximal small intestine (duodenum and jejunum) where calbindin and the calcium-pumping ATPAse are also found. The TRPV6 calcium transporter also found in the human placenta, pancreas and prostate gland and in some species in the kidney where the related channel TRPV5 is strongly expressed.
TRPV6 is a member of the Transient receptor potential family of membrane proteins.
Expression of TRPV6 appears to be vitamin D dependent as it is greatly reduced in animals that do not express the vitamin D receptor. Importantly, vitamin D treatment of colon cancer cells, Caco-2, also increases expression of TRPV6 gene. Vitamin D treatment of these cells also increases transport of calcium, probably via increasing TRPV6 expression.
[edit] References
Molecular cloning and characterization of a channel-like transporter mediating intestinal calcium absorption. Peng JB, Chen XZ, Berger UV, Vassilev PM, Tsukaguchi H, Brown EM, Hediger MA. J Biol Chem 1999; 274:22739-46. abstract
Epithelial calcium transporter expression in human duodenum. Barley NF, Howard A, O'Callaghan D, Legon S, Walters JR. Am J Physiol Gastrointest Liver Physiol. 2001; 280:G285-90. abstract
1,25-Dihydroxyvitamin D and 25-hydroxyvitamin D-mediated regulation of TRPV6 (a putative epithelial calcium channel) mRNA expression in Caco-2 cells. Taparia S, Fleet JC, Peng JB, Wang XD, Wood RJ. Eur J Nutr 2006;45(4):196-204. abstract
[edit] External links
Stretch-activated ion channel - Ligand-gated ion channel - Voltage-gated ion channel
Ca: Voltage-dependent calcium channel (L-type/CACNA1C, N-type, P-type, Q-type, R-type, T-type) - Inositol triphosphate receptor - Ryanodine receptor - Cation channels of sperm
Na: Sodium channel: SCN4A - SCN5A - SCN9A - Epithelial sodium channel /Amiloride-sensitive sodium channel
K: Potassium channel: Voltage-gated (KvLQT1, HERG, Shaker gene, KCNE1) - Calcium-activated (BK channel, SK channel) - Inward-rectifier (ROMK, KCNJ2) - Tandem pore domain/Resting ion channel
Cl: Chloride channel: Cystic fibrosis transmembrane conductance regulator
Transient receptor potential (TRPV6) - Cyclic nucleotide-gated ion channel - Two-pore channel
