Cefazolin
From Wikipedia, the free encyclopedia
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Cefazolin
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| Systematic (IUPAC) name | |
| 3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]- 8-oxo-7-([2-(tetrazol-1-yl)acetyl]amino)- 5-thia-1-azabicyclo[4.2.0] oct-2-ene-2-carboxylate |
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| Identifiers | |
| CAS number | |
| ATC code | J01 |
| PubChem | |
| Chemical data | |
| Formula | C14H14N8O4S3 |
| Mol. mass | 454.51 g/mol |
| Pharmacokinetic data | |
| Bioavailability | NA |
| Metabolism | ? |
| Half life | 1.8 hours (given IV) 2 hours (given IM) |
| Excretion | Renal, unchanged |
| Therapeutic considerations | |
| Pregnancy cat. | |
| Legal status |
℞ Prescription only |
| Routes | Intravenous, intramuscular |
Cefazolin (INN), also known as cefazoline or cephazolin, is a first generation cephalosporin antibiotic.
The drug is usually administrated either by intramuscular injection (injection into a large muscle) or intravenous infusion (intravenous fluid into a vein).
[edit] Indications
Cefazolin is mainly used to treat bacterial infections of the skin. It can also be used to treat moderately severe bacterial infections involving the lung, bone, joint, stomach, blood, heart valve, and urinary tract. It is effective only against infections caused by staphylococci and streptococci species of bacteria. These organisms are common on normal human skin. Resistance to cefazolin is seen in several species of bacteria.
[edit] Side effects
Side effects from cefazolin are not common. Possible side effects include:
- diarrhea
- stomach pain
- upset stomach
- vomiting
Cefazolin is marketed under the following brand names: Ancef®, Cefacidal®, Cefamezin®, Cefrina®, Elzogram®, Gramaxin®, Kefazol®, Kefol®, Kefzol®, Kefzolan®, Kezolin®, Novaporin®, and Zolicef®
[edit] External links
- MedlinePlus Drug Information: Cefazolin Sodium Injection.
- Eli Lilly Cefazolin Sodium Material Safety Data Sheet.
- Links to external chemical sources
| Cephalosporin Antibiotics (J01D) | |
|---|---|
| First Generation | Cefacetrile, Cefadroxil, Cefalexin, Cefaloglycin, Cefalonium, Cefaloridine, Cefalotin, Cefapirin, Cefatrizine, Cefazaflur, Cefazedone, Cefazolin, Cefradine, Cefroxadine, Ceftezole |
| Second Generation | Cefaclor, Cefamandole, Cefonicid, Ceforanide, Cefotiam, Cefprozil, Cefuroxime, Cefuzonam |
| Third Generation | Cefcapene, Cefdaloxime, Cefdinir, Cefditoren, Cefetamet, Cefixime, Cefmenoxime, Cefodizime, Cefoperazone, Cefotaxime, Cefpimizole, Cefpiramide, Cefpodoxime, Cefsulodin, Ceftazidime, Cefteram, Ceftibuten, Ceftiofur, Ceftiolene, Ceftizoxime, Ceftriaxone, Latamoxef |
| Fourth Generation | Cefclidine, Cefepime, Cefetecol,Cefluprenam, Cefoselis, Cefozopran, Cefpirome, Cefquinome |
