Hexobarbital

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Hexobarbital
Systematic (IUPAC) name
5-(1-cyclohexenyl)- 1,5-dimethyl- hexahydropyrimidine- 2,4,6-trione
Identifiers
CAS number	56-29-1
ATC code	N01AF02 N05 CA16
PubChem	3608
DrugBank	EXPT03301
Chemical data
Formula	C₁₂H₁₆N₂O₃
Mol. mass	236.267 g/mol
Pharmacokinetic data
Bioavailability	?
Protein binding	25%
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Hexobarbital is a barbiturate derivative having hypnotic and sedative effects. It was used in the 1940s-1950s as an agent for inducing anesthesia for surgery and has a relatively fast onset of effects and short duration of action. However it can be difficult to control the depth of anesthesia with hexobarbital which makes it quite dangerous, and it has now been replaced by safer drugs in human medicine, usually thiopental would be the barbiturate of choice for this application these days. Hexobarbital is still used in some scientific research.

[edit] External links

Takenoshita R, Toki S (2004). "[New aspects of hexobarbital metabolism: stereoselective metabolism, new metabolic pathway via GSH conjugation, and 3-hydroxyhexobarbital dehydrogenases]". Yakugaku Zasshi 124 (12): 857-71. PMID 15577260.
Wahlström G (1998). "A study of the duration of acute tolerance induced with hexobarbital in male rats.". Pharmacol Biochem Behav 59 (4): 945-8. PMID 9586853.
Korkmaz S, Ljungblad E, Wahlström G (1995). "Interaction between flumazenil and the anesthetic effects of hexobarbital in the rat.". Brain Res 676 (2): 371-7. PMID 7614008.
Dall V, Orntoft U, Schmidt A, Nordholm L (1993). "Interaction of the competitive AMPA receptor antagonist NBQX with hexobarbital.". Pharmacol Biochem Behav 46 (1): 73-6. PMID 8255925.

v • d • e

Barbiturates (N01AF, N03AA, N05CA)

Allobarbital, Amobarbital, Aprobarbital, Alphenal, Barbexaclone, Barbital, Butabarbital, Butalbital, Butobarbital, Butallylonal, Cyclobarbital, Cyclopal, Ethallobarbital, Hexethal, Heptabarbital, Hexobarbital, Mephobarbital, Metharbital, Methohexital, Methylphenobarbital, Narcobarbital, Pentobarbital, Probarbital, Proxibarbital, Propallylonal, Reposal, Secobarbital, Talbutal, Thialbarbital, Thiamylal, Thiobarbital, Thiobutabarbital Thiopental, Vinbarbital, Vinylbital

v • d • e General anesthetics (N01A)
Barbiturates	Hexobarbital, Methohexital, Narcobarbital, Thiopental
Ethers	Diethyl ether,Desflurane, Enflurane, Isoflurane, Methoxyflurane, Methoxypropane, Sevoflurane, Vinyl ether
Haloalkanes	Chloroform, Halothane, Trichloroethylene
Opioids	Alfentanil, Anileridine, Fentanyl, Phenoperidine, Remifentanil, Sufentanil
Others	Alfaxalone, Droperidol, Esketamine, Etomidate, Hydroxybutyric acid, Ketamine, Minaxolone, Nitrous oxide, Propanidid, Propofol, Xenon