Phenoperidine
From Wikipedia, the free encyclopedia
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Phenoperidine
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| Systematic (IUPAC) name | |
| ? | |
| Identifiers | |
| CAS number | |
| ATC code | N01 |
| PubChem | |
| Chemical data | |
| Formula | C23H29NO3 |
| Mol. mass | 367.481 |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | Liver |
| Half life | ? |
| Excretion | Bile and Urine |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status |
Proscription only |
| Routes | ? |
Phenoperidine, marketed as its hydrochloride as Operidine or Lealgin, is an opioid used as a general anesthetic. It is a derivative of isonipecotic acid, like pethidine, and is metabolized in part to norpethidine. It is 20-200 times as potent as pethidine as an analgesic.
Phenoperidine shares structural similarities with both pethidine and haloperidol (and related butyrophenone antipsychotics, e.g. droperidol). While not commonly used today in clinical practice, it is of historical interest as a precursor in the development of some of the most widely used neuroleptic drugs on the market today.
[edit] External links
- Kintz P, Godelar B, Mangin P, Lugnier A, Chaumont A (1989). "Simultaneous determination of pethidine (meperidine), phenoperidine, and norpethidine (normeperidine), their common metabolite, by gas chromatography with selective nitrogen detection.". Forensic Sci Int 43 (3): 267-73. PMID 2613140.
- Claris O, Bertrix L (1988). "Phenoperidine: pharmacology and use in pediatric resuscitation". Pediatrie 43 (6): 509-13. PMID 3186421.
- Antipsychotics - Reference pathway. Kyoto Encyclopedia of Genes and Genomes. Kanehisa Laboratories, Kyoto University, University of Tokyo. Retrieved on 2007-01-16.
- Claris, O. and Bertrix L.. "Phenoperidine: pharmacology and use in pediatric resuscitation". Pediatrie 43 (6): 509-13.
| General anesthetics (N01A) | |
|---|---|
| Barbiturates | Hexobarbital, Methohexital, Narcobarbital, Thiopental |
| Ethers | Diethyl ether,Desflurane, Enflurane, Isoflurane, Methoxyflurane, Methoxypropane, Sevoflurane, Vinyl ether |
| Haloalkanes | Chloroform, Halothane, Trichloroethylene |
| Opioids | Alfentanil, Anileridine, Fentanyl, Phenoperidine, Remifentanil, Sufentanil |
| Others | Alfaxalone, Droperidol, Esketamine, Etomidate, Hydroxybutyric acid, Ketamine, Minaxolone, Nitrous oxide, Propanidid, Propofol, Xenon |
Acetorphine, Acetyldihydrocodeine, Acetyldihydrocodeinone, Acetylmorphone, Alfentanil, Allylprodine, Alphaprodine, Anileridine, Bemidone, Benzylmorphine, beta-4-morpholinylethylmorphine, Betaprodine, Betmeprodine, Bezitramide, Buprenorphine, Butorphanol, Carfentanil, Clonitazene, Codeine, Codeine-N-Oxide, Codeinone, Cyclazocine, Cyclorphan, Desomorphine, Dextromoramide, Dextropropoxyphene, Dezocine, Diacetyldihydromorphine, Diethylthiambutene, Difenoxin, Dihydrocodeine, Dihydrocodeinone enol acetate, Dihydrohydroxycodeinone, Dihydrodesoxymorphine. Dihydroetorphine, Dihydroheroin, Dihydroisocodeine, Dihydromorphine, Dimethylthiambutene, Diphenoxylate, Dipipanone, Diprenorphine, Dipropanoylmorphine, Ethylketocyclazocine, Ethylmorphine, Etonitazene, Etorphine, Fentanyl, Diamorphine (Heroin), Hydrocodone, Hydromorphone, Isomethadone, Ketobemidone, Laudanum, Lefetamine, Levallorphan, Levo-alphacetylmethadol, Levomethorphan, Levomethadone, Levorphanol, Levopropoxyphene, Loperamide, Meptazinol, Metazocine, Methadone, Metopon, Monoacetylmorphine, Morphine-N-Oxide, Morphine, Morphinone, Morphine-6-glucuronide, MPPP, Myorphine, Nalbuphine, Nalmefene, Nalorphine, Naloxone, Naltrexone, Nicocodeine, Nicodicodeine, Nicomorphine, Norcodeine, N-allyl-normorphine, Ohmefentanyl, Omnopon, Opium, Oxycodone, Oxymorphone, Pantopon, Papaveretum, Paregoric, Pentazocine, PEPAP, Pethidine (Meperidine), Phenadoxone, Phenazocine, Phenoperidine, Pholcodeine, Piminodine, Piritramide, Prodine, Proheptazine, Propiram, Propoxyphene, Racemethorphan, Racemorphan, Remifentanil, Sufentanil, Tetrapon, Thebacon, Thebaine, Thiofentanil, Tilidine, Tramadol, Trimeperidine
| Analgesics (N02A, N02B) | |
|---|---|
| Opioids | Bezitramide, Buprenorphine, Butorphanol, Dextromoramide, Dextropropoxyphene, Diamorphine, Dihydrocodeine, Fentanyl, Hydromorphone, Ketobemidone, Methadone, Morphine, Nalbufine, Nicomorphine, Opium, Oxycodone, Papaveretum, Pethidine, Piritramide, Tramadol (see also longer list) |
| Salicylic acid and derivatives | Aspirin (Acetylsalicylic Acid), Diflunisal, Ethenzamide -- See also: NSAIDs |
| Pyrazolones | Aminophenazone, Metamizole, Phenazone |
| Anilides | Paracetamol (acetaminophen), Phenacetin |
| Others | Ziconotide, Tetrahydrocannabinol, Ibuprofen, Ketoprofen, Mefenamic Acid, Naproxen, Diclofenac, Flurbiprofen, Diflunisal, Fenoprofen, Indomethacin, Ketorolac, Meclofenamate, Meloxicam, Piroxicam, Tolmetin |
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