AIDS
From Simple English Wikipedia, the free encyclopedia
Acquired immunodeficiency syndrome or acquired immune deficiency syndrome (AIDS) is a syndrome caused by HIV.
- Acquired means that people get the disease from others who already have it.
- Immune or Immuno- talks about the immune system. The immune system is the part of the body that fights infectious disease.
- Deficiency means not enough. An immuno-deficiency is a problem where the immune system is damaged and cannot fight disease well.
- Syndrome is a disease that makes many different problems in your body.
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[edit] How many people have AIDS
About 3,000,000 people died because of AIDS in 2004. About 500,000 of these people were children. About 40,000,000 people in the world had HIV in 2004.
Most of the people who have HIV live in Africa. Most of the children who die from AIDS live in Africa.
Many people with HIV do not know they have it. The number of people with HIV is unknown.
HIV/AIDS is an epidemic.
[edit] Where did HIV come from?
Scientists believe the first person who got HIV was a person in Africa. Scientists think this happened between 1915 to 1941. This happened when Simian Immunodeficiency Virus (SIV) went from chimpanzees to humans.
[edit] What does HIV do in the body
HIV hurts the immune system. This is how the body fights infections. This is also how the body helps stop cancers. So people with HIV have more infections and cancers.
[edit] HIV and AIDS
Not every person who has HIV has AIDS. When people first get HIV they are not very sick. They can be healthy for years. When they get sick from HIV it is called AIDS.
If someone has HIV they are called HIV positive.
Someone has AIDS if they have HIV and either:
- Blood tests that show very low numbers of special cells that fight infections
- AIDS defining illnesses (illness is another word for disease.)
[edit] AIDS defining illnesses
Some of the infections and cancers that people with AIDS get are not common. People who have good immune systems do not get these diseases. Many of these diseases are called AIDS defining illnesses. Some AIDS defining illnesses are:
- Kaposi's sarcoma – a cancer that usually is on the skin
- CMV retinitis – a virus that infects the back of the eye
- Pneumocystis carinii pneumonia (acronym PCP) – an infectious disease of the lung. PCP is the most common infection in AIDS patients.
- Toxoplasmosis – an infectious disease that can be in the brain
- Invasive cervical cancer – this is cancer of the bottom part of a woman's uterus. Invasive means the cancer has spread.
[edit] CD4 T-cell count
The blood test that defines AIDS is the CD4 T-cell count. T-cells are white blood cells. These are cells that fight infection. HIV goes into T-cells and kills them. When HIV infection gets very bad the number of CD4 T-cells in the blood goes down. CD4 is a protein outside of the T-cell. Some T-cells have this protein. They are called CD4 positive T-cells, CD4 T-cells or sometimes T4 cells.
When someone has HIV and their CD4 T-cell count (number of cells in the blood) is below 200 cells/microliter it means they have AIDS.
[edit] Treatment of HIV and AIDS
There are medicines that help people with AIDS. These are called antiretroviral medicines (or antiretrovirals.) Anti- means against. HIV is a retrovirus. So antiretroviral means fights retroviruses.
Antiretrovirals cannot cure AIDS. This means they cannot make all of the virus leave a persons body. But they can make people with AIDS more healthy. Antiretrovirals help people fight the HIV virus. This makes their immune systems work better. So antiretrovirals are a treatment but not a cure for HIV.
People with HIV/AIDS who take antiretroviral medicines live longer. They live more years without getting AIDS defining illnesses. But after a long time, the HIV virus learns how to fight the antiretrovirals. The HIV learns to not be killed by the medicines. HIV that learns this is resistant to the medicine. Then the resistant HIV hurts the immune system and the person gets AIDS.
Sometimes when HIV is resistant to one medicine, another medicine can be used. To make less resistance happen, people with AIDS take more than one medicine at the same time. They may take 2-4 medicines at once. This is sometimes called a cocktail or AIDS cocktail. Cocktail is a drink made of more than one kind of alcohol. So a cocktail is sometimes used to mean something made from different types of things.
When HIV gets resistant to one medicine, this is changed to another medicine. So the AIDS cocktail that people with AIDS take changes over time. But after a long time, the HIV learns to be resistant to many drugs. This is called multi-drug-resistant (acronym MDR) HIV. After the HIV in a person becomes MDR-HIV there may be no more medicines to treat them. So scientists keep trying to find new medicines to fight HIV.
The five most important HIV medicines are:
- D4T (stavudine)
- 3TC (Lamivudine)
- NVP (nevirapine)
- AZT (zidovudine)
- EFZ (efavirenz)
[edit] Poverty and HIV
Even though there are medicines to treat HIV, most people in the world who have HIV do not get medicine. (Another word for medicine is drug.) Only 15% of the people in the world who need HIV drugs get them. Most of the people who get them live in wealthy (not poor) countries.
Poor countries cannot pay for antiretroviral drugs. One of the reasons they cannot buy medicines is the drugs are very expensive (cost very much money.) In the USA and Europe, the cost for medicines for a person with AIDS can be more than $1000 every month.
The continent with the most people with HIV is the poorest: Africa.
The corporations (businesses) that make these drugs sell the medicine at a higher price than it costs them to make the drugs. They do this to make a profit (money). Some drug companies use a part of these profits to do research to find and make new drugs. Almost all of the money they make from the drugs is in wealthy countries like France and Canada.
Many corporations that make medicines do not want to sell them for less money in poor countries. They say this is because the drugs will be brought back to countries with more money, and that this will make them not sell as much in wealthy countries.
Some people want other countries or corporations to make the medicines. Most of the them cannot do this because the drugs are patented. This means the person or corporation that discovered (found) the drug can say who makes the drug. People can only make the drug if they pay money to the patent-holder (person who has the patent.) Once the patent on a drug expires, then another company is legally allowed to make that drug (this is called a generic drug.) The patent does not expire on most drugs for at least 17 years. This is very important with medicines that fight infections. Drugs to fight infections may not work as well after we use them for many years. This is because the bacteria or virus may become resistant to the medicine.
Some countries are breaking the laws about patents. They say that helping poor people with AIDS is much more important than following patent laws. Brazil and Cuba are two of the countries that do this.
[edit] How can we stop AIDS?
There are many ways people fight the AIDS epidemic.
[edit] Education
The most important way to stop HIV/AIDS is education. People can get HIV from sex and from blood. Children can also get HIV from their mothers (when they grow inside pregnant mothers and when they drink breast milk.) Sex is one way to get HIV. If people use condoms when they have sex, they get HIV much less.
You can also get HIV by sharing needles. This means using a dirty (not clean) needle after someone else has used it. Some people who take illegal drugs like heroin and cocaine take these drugs by needle. Some of these people share needles. If one person has HIV and he shares his needles, he can give HIV to other people. But if people have clean needles or if they know how to clean needles, they do not get HIV as much.
Many people do not know that condoms and clean needles help stop HIV. They may not even know that sharing needles and sex with someone who has HIV can make them get HIV. Even if people know about condoms and clean needles, they may not have condoms and clean needles.
[edit] Safe sex and needle exchange
There are some people who do not want people to know about condoms or clean needles, or do not want people to have condoms or clean needles. They believe that if people know about condoms and have condoms they will have more sex. They believe that if people have clean needles they will use illegal drugs more. Many of these people think this because of their religion. For example, the Catholic church does not want people to have or use condoms. They do not want people to have condoms because they do not think people should have sex unless they are married. They also think that married people should not use condoms, because they believe that if people have sex, it should only be to make a baby.
Scientists who study (look at and learn about) people who use condoms, see that if teenagers (children 13-19) learn about condoms (and other birth control) they have less unsafe sex. Scientists see that learning about these things does not make teenagers start having sex earlier. The teenagers also have safer sex. Safer sex means doing things (like wearing condoms) to try not to get pregnant or get sexually transmitted diseases (STDs or STIs) like HIV, gonorrhea, and syphilis. Using a condom works very well for keeping people from getting pregnant or getting STDs if people know how to use a condom the right way.[1] [2]
Scientists have also learned that if a city has a needle exchange program they have less people who use illegal drugs. Needle exchange programs are where people can come in and trade dirty needles for clean needles. This means that if they use drugs they will be more safe. But needle exchange programs do more than give people clean needles. They teach people about drugs. If people want to stop using drugs, they help them. [3]
[edit] HIV vaccine
The best way to stop HIV is a vaccine. There is no vaccine for HIV yet. Many scientists are looking for an HIV vaccine. Even one that protected some people from HIV would save millions of people's lives.
[edit] Alternative ideas
Some scientists think that HIV is not the cause of AIDS. They think AIDS is the result of illegal drug use, drugs used to treat HIV infection, malnutrition, poverty, multiple infections, and other assaults on the immune system. Most scientists disagree with this viewpoint and feel the evidence for HIV as the cause of AIDS is overwhelming. See the external links below.
[edit] External links
These may be unsimple.
- World Health Organizations 3 by 5 Initiative
- Médecins Sans Frontières: Campaign for Access to Essential Medicines
- WHO HIV/AIDS Programme
- AIDS Education Global Information System
- From the US National Institutes of Health
- New England Journal of Medicine Article "Patents versus Patients? Antiretroviral Therapy in India"
- AIDSPortal knowledge network
[edit] Alternative ideas
These may be unsimple.
[edit] References
- ^ "Survey shows intervention crucial to halt HIV in youth." AIDS Policy Law. 2005 Mar 11;20(5):4.
- ^ "Sexual possibility situations and sexual behaviors among young adolescents: the moderating role of protective factors." J Adolesc Health. 2004 Dec;35(6):528.e11-20.
- ^ "Update: syringe exchange programs--United States, 2002." Morb Mortal Wkly Rep. 2005 Jul 15;54(27):673-6. (MMWR is published by the Centers for Disease Control.
