Piritramide
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Piritramide
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| Systematic (IUPAC) name | |
| 1-(3-cyano-3,3-diphenyl-propyl)-4-(1-piperidyl)piperidine-4-carboxamide | |
| Identifiers | |
| CAS number | |
| ATC code | ? |
| PubChem | |
| Chemical data | |
| Formula | C27H34N4O |
| Mol. mass | 430.585 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | Oral, IM, IV |
Piritramide (Pirinitramide) is a synthetic opioid analgesic which is commonly used for the treatment of postoperative pain. Piritramide was discovered at Janssen Pharmaceutica in 1960. Piritramide is available in tablets and solution for injection, and is used in Patient Controlled Analgesia units. In addition to PCA, piritramide is most often used in post-operative situations and emergency departments; some of its properties would seem to lend it well to chronic pain control as well.
Piritramide is also known as pirinitramide. Its closest chemical relative amongst well-known drugs is bezitramide (Burgodin®)
Piritramide's most common trade name is Dipidolor® and it is used most heavily in the Netherlands, Denmark, and Germany.
Piritramide is a strong opioid and therefore is regulated much the same as morphine in all known jurisdictions. It has a small but dedicated community of recreational users and it has the street names P, Dip (rhymes with "pipe") and Pierrette.
[edit] References
- Janssen PA, Pirinitramide (R 3365), a potent analgesic with unusual chemical structure, J Pharm Pharmacol. 1961 Sep;13:513-30.
- Kay B, A clinical investigation of piritramide in the treatment of postoperative pain, Br J Anaesth. 1971 Dec;43(12):1167-71.
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